ZSWIM6

Across TCGA pan-cancer cohorts, ZSWIM6 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZSWIM6 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ZSWIM6 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZSWIM6 expression acts as an unfavorable survival marker.

ACC, LIHC, and BRCA are the cancer types where ZSWIM6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.128	0.706	<.001	24	view →
LIHC	DFS	Median	All	0.125	0.548	<.001	15	view →
BRCA	OS	Median	III,IV	0.667	0.907	<.001	10	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZSWIM6–ACC (OS)

Open the ACC breakdown →