ZSWIM6

Across TCGA patient cohorts, ZSWIM6 mutation is significantly associated with the RNA expression of many other genes, with 2,689 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSWIM6-associated genes across cancer lineages are RNU6-495P, RNU6-468P, and RPL23AP16. Each is linked with ZSWIM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSWIM6-to-partner and partner-to-ZSWIM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-495P grouped by ZSWIM6-low versus ZSWIM6-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM6→partner) and Y-score (partner→ZSWIM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNU6-495P →	+0.353	+4.100	.007	.005	3	2
LIHC	RNU6-468P →	+0.267	+5.593	<.001	<.001	3	2
CESC	RPL23AP16 →	+0.079	+4.269	<.001	.002	3	2
UCEC	COX15 →	+0.391	+2.815	.002	.001	3	2
UCEC	ATP5F1A →	+0.494	+3.775	<.001	<.001	3	2
UCEC	SKA1 →	+0.704	+2.470	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,689 associations by consensus.

RNU6-495P by ZSWIM6 expression — LIHC

Explore this box plot interactively →