ZSWIM6

Across TCGA patient cohorts, ZSWIM6 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSWIM6-associated genes across cancer lineages are ASNS, 4E-BP1, and TSC1. Each is linked with ZSWIM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSWIM6-to-partner and partner-to-ZSWIM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ZSWIM6-low versus ZSWIM6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM6→partner) and Y-score (partner→ZSWIM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.353	+1.700	.010	.042	3	2
UCEC	4E-BP1 →	+0.326	+3.459	.001	.005	3	2
COAD	TSC1 →	-0.365	-2.991	.010	.036	3	1
UCEC	EGFR_pY1068 →	-0.224	-2.087	.019	.005	3	1
UCEC	ERK2 →	+0.170	+2.087	.021	.005	3	1
UCEC	FASN →	+0.376	+2.321	.012	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ASNS by ZSWIM6 expression — UCEC

Explore this box plot interactively →