ZSWIM6

Across TCGA cell cohorts, ZSWIM6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,011 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZSWIM6-associated GO terms across cancer lineages are Protein targeting to vacuole, Negative regulation of myoblast fusion, and Striatal medium spiny neuron differentiation. Each is linked with ZSWIM6 in more than 13 cancer types. Because this analysis shows association rather than direction, both ZSWIM6-to-partner and partner-to-ZSWIM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to vacuole grouped by ZSWIM6-low versus ZSWIM6-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM6→partner) and Y-score (partner→ZSWIM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Protein targeting to vacuole →	+0.080	+0.635	<.001	<.001	3	14
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.170	+1.006	.002	.001	3	14
BLOOD_Myeloma	Striatal medium spiny neuron differentiation →	+1.213	+1.420	<.001	<.001	3	14
OESOPHAGUS	Regulation of cell-substrate junction organization →	+0.141	+1.050	<.001	.001	3	13
OESOPHAGUS	Regulation of focal adhesion assembly →	+0.160	+1.061	<.001	.003	3	13
OESOPHAGUS	Regulation of cell-substrate junction assembly →	+0.160	+1.061	<.001	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,011 associations by consensus.

Protein targeting to vacuole by ZSWIM6 expression — UPPER_AERODIGESTIVE_TRACT

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