ZSWIM6

Across TCGA cell cohorts, ZSWIM6 mutation is significantly associated with the RNA expression of many other genes, with 952 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZSWIM6-associated genes across cancer lineages are ADAM7, LY6G6F, and PRSS58. Each is linked with ZSWIM6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZSWIM6-to-partner and partner-to-ZSWIM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM7 grouped by ZSWIM6-low versus ZSWIM6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM6→partner) and Y-score (partner→ZSWIM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ADAM7 →	+0.003	+2.667	<.001	<.001	3	3
BONE	LY6G6F →	+0.020	+5.169	<.001	.004	3	1
PANCREAS	PRSS58 →	+0.092	+5.000	<.001	.006	3	1
CNS	CRP →	+0.240	+4.169	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	CELA1 →	+0.078	+3.917	<.001	.004	3	1
UPPER_AERODIGESTIVE_TRACT	SPEM1 →	+0.114	+3.722	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 952 associations by consensus.

ADAM7 by ZSWIM6 expression — LARGE_INTESTINE

Explore this box plot interactively →