ZSWIM5P3

Across TCGA pan-cancer cohorts, ZSWIM5P3 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZSWIM5P3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZSWIM5P3 RNA is repressed in tumor relative to normal tissue. In most cancer types ZSWIM5P3 is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, BLCA, and KIRC are the cancer types where ZSWIM5P3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZSWIM5P3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.007	.006	4	view →
BLCA	All	All	−0.072	.021	3	view →
KIRC	Male	All	+0.015	.019	3	view →
KIRP	Female	All	+0.026	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ZSWIM5P3–THCA

Open the THCA breakdown →