ZSWIM5

Across TCGA patient cohorts, ZSWIM5 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSWIM5-associated genes across cancer lineages are CD31, MEK1, and Cyclin-B1. Each is linked with ZSWIM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZSWIM5-to-partner and partner-to-ZSWIM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD31 grouped by ZSWIM5-low versus ZSWIM5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM5→partner) and Y-score (partner→ZSWIM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	CD31 →	-0.298	-3.169	<.001	.018	3	3
UCEC	MEK1 →	+0.443	+2.169	.001	.003	3	3
UCEC	Cyclin-B1 →	+0.766	+2.662	<.001	<.001	3	3
SKCM	XRCC1 →	+0.170	+2.459	.045	.020	3	3
UCEC	A-Raf_pS299 →	-0.160	-2.115	<.001	.017	3	2
UCEC	MSH2 →	-0.278	-1.973	.001	.029	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

CD31 by ZSWIM5 expression — LUSC

Explore this box plot interactively →