ZSWIM5

Across TCGA cell cohorts, ZSWIM5 mutation is significantly associated with the RNA expression of many other genes, with 715 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZSWIM5-associated genes across cancer lineages are OR4X2, CCDC182, and RAX. Each is linked with ZSWIM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSWIM5-to-partner and partner-to-ZSWIM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by ZSWIM5-low versus ZSWIM5-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM5→partner) and Y-score (partner→ZSWIM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR4X2 →	+0.036	+5.000	<.001	.005	3	2
STOMACH	CCDC182 →	+0.025	+4.285	<.001	.007	3	2
BLOOD_Leukemia	RAX →	+0.294	+3.536	<.001	.001	3	2
KIDNEY	OR2T35 →	+0.023	+5.000	<.001	.005	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
OVARY	OR11H2 →	+0.046	+4.450	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 715 associations by consensus.

OR4X2 by ZSWIM5 expression — KIDNEY

Explore this box plot interactively →