ZSWIM4

Across TCGA patient cohorts, ZSWIM4 mutation is significantly associated with the RNA expression of many other genes, with 2,213 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSWIM4-associated genes across cancer lineages are RNU6-751P, SPATA31A5, and KRTAP9-7. Each is linked with ZSWIM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZSWIM4-to-partner and partner-to-ZSWIM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-751P grouped by ZSWIM4-low versus ZSWIM4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM4→partner) and Y-score (partner→ZSWIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-751P →	+0.316	+5.040	<.001	.002	3	3
BRCA	SPATA31A5 →	+0.006	+7.471	<.001	.008	3	2
BLCA	KRTAP9-7 →	+0.361	+4.251	<.001	.001	3	2
BLCA	KRTAP19-6 →	+0.468	+6.640	<.001	<.001	3	2
COAD	RNA5SP477 →	+0.991	+3.685	<.001	.003	3	2
COAD	CDC27P2 →	+0.049	+3.452	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,213 associations by consensus.

RNU6-751P by ZSWIM4 expression — BLCA

Explore this box plot interactively →