ZSWIM4

Across TCGA cell cohorts, ZSWIM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,513 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZSWIM4-associated GO terms across cancer lineages are Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration, Regulation of vacuole organization, and Endosomal transport. Each is linked with ZSWIM4 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZSWIM4-to-partner and partner-to-ZSWIM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration grouped by ZSWIM4-low versus ZSWIM4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM4→partner) and Y-score (partner→ZSWIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration →	+0.171	+0.985	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of vacuole organization →	+0.085	+1.291	<.001	<.001	3	13
STOMACH	Endosomal transport →	+0.071	+1.257	<.001	.002	3	13
LARGE_INTESTINE	Regulation of intracellular steroid hormone receptor signaling pathway →	+0.073	+0.693	<.001	.003	3	13
LIVER	Regulation of glycolytic process through fructose-6-phosphate →	+0.167	+1.518	<.001	.004	3	13
LIVER	Negative regulation of glycolytic process through fructose-6-phosphate →	+0.167	+1.518	<.001	.004	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,513 associations by consensus.

Modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration by ZSWIM4 expression — LARGE_INTESTINE

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