ZSWIM4

Across TCGA cell cohorts, ZSWIM4 mutation is significantly associated with the RNA expression of many other genes, with 436 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZSWIM4-associated genes across cancer lineages are HMGXB4, ARMC1, and MAPK8. Each is linked with ZSWIM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSWIM4-to-partner and partner-to-ZSWIM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGXB4 grouped by ZSWIM4-low versus ZSWIM4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM4→partner) and Y-score (partner→ZSWIM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HMGXB4 →	+0.644	+3.502	<.001	.001	3	2
LARGE_INTESTINE	ARMC1 →	+0.436	+3.502	.002	.001	3	2
LARGE_INTESTINE	MAPK8 →	+0.674	+3.675	.003	<.001	3	2
LARGE_INTESTINE	TRIM37 →	+0.645	+3.502	.001	.001	3	2
LARGE_INTESTINE	APBA3 →	+0.528	+3.502	.004	.001	3	2
LARGE_INTESTINE	TUT4 →	+0.951	+3.502	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 436 associations by consensus.

HMGXB4 by ZSWIM4 expression — LARGE_INTESTINE

Explore this box plot interactively →