ZSWIM3

Across TCGA cell cohorts, ZSWIM3 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZSWIM3-associated genes across cancer lineages are TBL1Y, SERPINA7, and OR1L6. Each is linked with ZSWIM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSWIM3-to-partner and partner-to-ZSWIM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBL1Y grouped by ZSWIM3-low versus ZSWIM3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSWIM3→partner) and Y-score (partner→ZSWIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUAD	SERPINA7 →	+0.006	+5.228	.005	.005	3	1
LUNG_NSCLC_LUAD	OR1L6 →	+0.019	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	TARM1 →	+0.032	+5.662	<.001	.002	3	1
LARGE_INTESTINE	COQ5 →	+0.547	+3.364	.002	.002	3	1
LARGE_INTESTINE	RFX4 →	+0.027	+2.252	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

TBL1Y by ZSWIM3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →