ZSCAN9

Across TCGA patient cohorts, ZSCAN9 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN9-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and INPP4B. Each is linked with ZSCAN9 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN9-to-partner and partner-to-ZSCAN9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZSCAN9-low versus ZSCAN9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN9→partner) and Y-score (partner→ZSCAN9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.344	-3.169	.004	.019	3	1
UCEC	A-Raf_pS299 →	-0.184	-2.321	.001	.034	3	1
UCEC	INPP4B →	-0.428	-3.321	.006	.010	3	1
UCEC	JNK2 →	+0.344	+2.459	<.001	.020	3	1
UCEC	Ku80 →	+0.283	+2.472	.013	.011	3	1
UCEC	MEK1 →	+0.601	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

EGFR_pY1068 by ZSCAN9 expression — UCEC

Explore this box plot interactively →