ZSCAN4

Across TCGA cell cohorts, ZSCAN4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZSCAN4-associated genes across cancer lineages are DMRTB1, COX6A2, and DEFB124. Each is linked with ZSCAN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN4-to-partner and partner-to-ZSCAN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMRTB1 grouped by ZSCAN4-low versus ZSCAN4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN4→partner) and Y-score (partner→ZSCAN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DMRTB1 →	+0.006	+4.887	<.001	.009	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	DEFB124 →	+0.082	+3.347	<.001	.005	3	1
SKIN	NLRP8 →	+0.018	+3.977	<.001	.001	3	1
SKIN	AKAIN1 →	+0.062	+3.345	<.001	.007	3	1
LARGE_INTESTINE	SCN7A →	+0.029	+3.232	<.001	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

DMRTB1 by ZSCAN4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →