ZSCAN32

Across TCGA patient cohorts, ZSCAN32 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN32-associated genes across cancer lineages are Myosin-IIa_pS1943, NF2, and p62 Lck ligand. Each is linked with ZSCAN32 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN32-to-partner and partner-to-ZSCAN32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by ZSCAN32-low versus ZSCAN32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN32→partner) and Y-score (partner→ZSCAN32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.167	+1.920	.044	.009	3	2
UCEC	NF2 →	+0.260	+2.000	.002	.029	3	2
UCEC	p62 Lck ligand →	+0.562	+4.169	<.001	<.001	3	2
UCEC	ATM →	-0.433	-3.087	.017	<.001	3	2
UCEC	14-3-3_beta →	-0.126	-3.295	.001	.009	3	1
UCEC	A-Raf_pS299 →	-0.165	-2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Myosin-IIa_pS1943 by ZSCAN32 expression — UCEC

Explore this box plot interactively →