ZSCAN32

Across TCGA cell cohorts, ZSCAN32 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ZSCAN32-associated genes across cancer lineages are IL22, NR0B2, and STRA8. Each is linked with ZSCAN32 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN32-to-partner and partner-to-ZSCAN32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL22 grouped by ZSCAN32-low versus ZSCAN32-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN32→partner) and Y-score (partner→ZSCAN32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IL22 →	+0.010	+4.022	<.001	.006	3	1
SKIN	NR0B2 →	+0.051	+3.643	.001	.004	3	1
SKIN	STRA8 →	+0.023	+3.345	<.001	.007	3	1
SKIN	CHRNB3 →	+0.009	+3.882	<.001	.001	3	1
SKIN	C8orf74 →	+0.064	+3.345	<.001	.007	3	1
SKIN	HES3 →	+0.041	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IL22 by ZSCAN32 expression — SKIN

Explore this box plot interactively →