ZSCAN31

Across TCGA patient cohorts, ZSCAN31 mutation is significantly associated with the RNA expression of many other genes, with 1,955 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN31-associated genes across cancer lineages are NIPA1, RRM2, and KNSTRN. Each is linked with ZSCAN31 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZSCAN31-to-partner and partner-to-ZSCAN31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NIPA1 grouped by ZSCAN31-low versus ZSCAN31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN31→partner) and Y-score (partner→ZSCAN31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NIPA1 →	+0.797	+2.545	<.001	<.001	3	3
UCEC	RRM2 →	+0.767	+2.436	<.001	.001	3	3
SKCM	KNSTRN →	+0.833	+3.341	<.001	.005	3	2
SKCM	PSMC3IP →	+0.763	+3.379	<.001	.005	3	2
SKCM	EME1 →	+0.784	+3.341	<.001	.005	3	2
UCEC	PACSIN2 →	+0.478	+1.807	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,955 associations by consensus.

NIPA1 by ZSCAN31 expression — UCEC

Explore this box plot interactively →