ZSCAN31

Across TCGA patient cohorts, ZSCAN31 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN31-associated genes across cancer lineages are p62 Lck ligand, PDCD4, and 4E-BP1. Each is linked with ZSCAN31 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN31-to-partner and partner-to-ZSCAN31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ZSCAN31-low versus ZSCAN31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN31→partner) and Y-score (partner→ZSCAN31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.463	+2.916	<.001	<.001	3	2
UCEC	PDCD4 →	-0.516	-1.797	.002	.025	3	2
UCEC	4E-BP1 →	+0.252	+1.502	.011	.030	3	2
UCEC	EGFR_pY1068 →	-0.240	-2.700	.009	.005	3	1
UCEC	eIF4E →	+0.158	+3.183	.041	.009	3	1
UCEC	IGFBP2 →	-0.654	-1.502	.006	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

p62 Lck ligand by ZSCAN31 expression — UCEC

Explore this box plot interactively →