ZSCAN29

Across TCGA pan-cancer cohorts, ZSCAN29 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZSCAN29’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZSCAN29 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZSCAN29 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where ZSCAN29 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZSCAN29 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.281	<.001	12	view →
BLCA	All	All	+0.636	<.001	9	view →
LIHC	Female	II,III,IV	+0.938	<.001	8	view →
THCA	All	II,III,IV	−0.513	<.001	8	view →
STAD	Male	II,III,IV	+0.942	<.001	6	view →
CHOL	All	All	+1.761	<.001	5	view →
LUSC	Male	All	+0.441	<.001	5	view →
KIRC	All	All	+0.330	<.001	5	view →
BRCA	All	II,III,IV	+0.186	.014	4	view →
ESCA	Female	All	+0.773	.008	2	view →
COAD	Male	All	+0.317	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZSCAN29–HNSC

Open the HNSC breakdown →