Across TCGA pan-cancer cohorts, ZSCAN26 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZSCAN26’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where ZSCAN26 RNA is repressed in tumor relative to normal tissue. In most cancer types ZSCAN26 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
THCA, LIHC, and KIRC are the cancer types where ZSCAN26 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZSCAN26 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.