Across TCGA pan-cancer cohorts, ZSCAN23 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ZSCAN23 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ZSCAN23 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZSCAN23 expression acts as an unfavorable survival marker.

SKCM and BRCA are the cancer types where ZSCAN23 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.179	0.781	<.001	9	view →
BRCA	DFS	Median	II,III,IV	0.585	0.889	.003	4	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: ZSCAN23 tumor-vs-normal RNA expression · all ZSCAN23 data types