ZSCAN22

Across TCGA patient cohorts, ZSCAN22 mutation is significantly associated with the RNA expression of many other genes, with 694 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN22-associated genes across cancer lineages are OR12D1, RNU6-789P, and TRAJ43. Each is linked with ZSCAN22 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN22-to-partner and partner-to-ZSCAN22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR12D1 grouped by ZSCAN22-low versus ZSCAN22-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN22→partner) and Y-score (partner→ZSCAN22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	OR12D1 →	+0.105	+6.257	<.001	.001	3	2
READ	RNU6-789P →	+0.730	+5.039	<.001	.008	3	2
UCEC	TRAJ43 →	+0.546	+2.041	.001	.003	3	2
UCEC	RN7SKP286 →	+0.042	+3.890	<.001	.007	3	2
HNSC	RPL26P3 →	+0.119	+4.624	.006	.004	3	2
HNSC	RNU6-750P →	+0.314	+4.822	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 694 associations by consensus.

OR12D1 by ZSCAN22 expression — READ

Explore this box plot interactively →