ZSCAN22

Across TCGA patient cohorts, ZSCAN22 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN22-associated genes across cancer lineages are SF2, Caspase-7-cleavedD198, and 14-3-3_beta. Each is linked with ZSCAN22 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN22-to-partner and partner-to-ZSCAN22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF2 grouped by ZSCAN22-low versus ZSCAN22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN22→partner) and Y-score (partner→ZSCAN22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SF2 →	-0.160	-1.990	<.001	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.682	+2.479	.005	.010	3	2
UCEC	14-3-3_beta →	-0.129	-2.308	.001	.006	3	1
UCEC	EGFR_pY1068 →	-0.259	-1.807	.012	.027	3	1
UCEC	eIF4E →	+0.215	+2.700	.013	.006	3	1
UCEC	JNK2 →	+0.221	+3.026	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

SF2 by ZSCAN22 expression — UCEC

Explore this box plot interactively →