ZSCAN21

Across TCGA patient cohorts, ZSCAN21 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN21-associated genes across cancer lineages are MEK1, C-Raf, and Ku80. Each is linked with ZSCAN21 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN21-to-partner and partner-to-ZSCAN21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZSCAN21-low versus ZSCAN21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN21→partner) and Y-score (partner→ZSCAN21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.493	+3.459	.002	.005	3	2
UCEC	C-Raf →	+0.202	+2.000	.001	.032	3	2
UCEC	Ku80 →	+0.294	+2.820	.005	.035	3	1
UCEC	Notch1 →	+0.228	+3.469	<.001	.002	3	1
UCEC	p62 Lck ligand →	+0.425	+3.807	.003	<.001	3	1
UCEC	TFRC →	+0.514	+2.999	.031	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MEK1 by ZSCAN21 expression — UCEC

Explore this box plot interactively →