ZSCAN21

Across TCGA cell cohorts, ZSCAN21 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZSCAN21-associated genes across cancer lineages are MAGEB4, OBP2A, and APLNR. Each is linked with ZSCAN21 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN21-to-partner and partner-to-ZSCAN21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by ZSCAN21-low versus ZSCAN21-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN21→partner) and Y-score (partner→ZSCAN21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.014	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	OBP2A →	+0.131	+2.878	<.001	.009	3	1
LARGE_INTESTINE	APLNR →	+0.245	+3.478	.001	.005	3	1
LARGE_INTESTINE	ZNF804B →	+0.015	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	IFIT1B →	+0.030	+3.145	<.001	.004	3	1
LARGE_INTESTINE	CCDC195 →	+0.045	+3.297	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MAGEB4 by ZSCAN21 expression — LARGE_INTESTINE

Explore this box plot interactively →