ZSCAN20

Across TCGA patient cohorts, ZSCAN20 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN20-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and eIF4E. Each is linked with ZSCAN20 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZSCAN20-to-partner and partner-to-ZSCAN20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZSCAN20-low versus ZSCAN20-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN20→partner) and Y-score (partner→ZSCAN20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.132	+3.016	.001	.018	3	6
UCEC	PCNA →	+0.289	+2.807	<.001	<.001	3	4
UCEC	eIF4E →	+0.213	+3.713	.001	<.001	3	3
UCEC	Rictor_pT1135 →	-0.081	-1.765	.011	.013	3	3
COAD	FoxM1 →	+0.371	+3.467	.021	.002	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.310	-1.124	.028	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Caspase-7-cleavedD198 by ZSCAN20 expression — COAD

Explore this box plot interactively →