ZSCAN2

Across TCGA pan-cancer cohorts, ZSCAN2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZSCAN2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZSCAN2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZSCAN2 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where ZSCAN2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZSCAN2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.678	<.001	12	view →
BLCA	Female	III,IV	+1.041	<.001	10	view →
LIHC	Female	II,III,IV	+1.336	<.001	9	view →
LUAD	Male	II,III,IV	+1.121	<.001	9	view →
COAD	Male	All	+0.488	<.001	9	view →
STAD	Male	II,III,IV	+0.842	<.001	6	view →
LUSC	Male	II,III,IV	+0.547	<.001	6	view →
CHOL	Female	All	+2.226	<.001	5	view →
KIRC	Female	All	+0.471	.010	3	view →
PRAD	All	All	+0.674	<.001	2	view →
UCEC	All	II,III,IV	+0.599	.037	2	view →
KICH	All	All	−0.381	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZSCAN2–HNSC

Open the HNSC breakdown →