ZSCAN18

Across TCGA patient cohorts, ZSCAN18 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN18-associated genes across cancer lineages are p38-MAPK_pT180_Y182, A-Raf_pS299, and Rab25. Each is linked with ZSCAN18 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZSCAN18-to-partner and partner-to-ZSCAN18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by ZSCAN18-low versus ZSCAN18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN18→partner) and Y-score (partner→ZSCAN18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.379	-2.000	.013	.009	3	4
UCEC	A-Raf_pS299 →	-0.156	-2.502	<.001	.001	3	2
UCEC	Rab25 →	-0.247	-1.874	.028	.049	3	2
UCEC	ASNS →	+0.299	+1.874	.015	.049	3	2
UCEC	BRD4 →	+0.286	+2.584	.002	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.555	+2.019	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

p38-MAPK_pT180_Y182 by ZSCAN18 expression — UCEC

Explore this box plot interactively →