Across TCGA pan-cancer cohorts, ZSCAN16 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ZSCAN16 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ZSCAN16 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZSCAN16 expression acts as an unfavorable survival marker.

UVM and BRCA are the cancer types where ZSCAN16 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.075	0.859	<.001	36	view →
BRCA	OS	Median	III,IV	0.200	0.833	<.001	28	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: ZSCAN16 tumor-vs-normal RNA expression · all ZSCAN16 data types