ZSCAN16-AS1

Across TCGA pan-cancer cohorts, ZSCAN16-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ZSCAN16-AS1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher ZSCAN16-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ZSCAN16-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and KIRP show a favorable association.

SKCM, MESO, and KIRP are the cancer types where ZSCAN16-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.712	0.837	<.001	80	view →
MESO	DFS	Median	III,IV	0.523	0.289	.003	68	view →
KIRP	OS	Tertile	II,III,IV	0.826	0.192	.007	53	view →
LUAD	DFS	Median	All	0.840	0.740	<.001	35	view →
PAAD	OS	Tertile	All	0.563	0.306	.004	34	view →
OV	OS	Tertile	III,IV	0.745	0.637	.006	28	view →
COAD	DFS	Median	All	0.408	0.739	.006	27	view →
ESCA	DFS	Tertile	All	0.893	0.294	.010	21	view →
PRAD	DFS	Median	All	0.842	0.925	.002	18	view →
THYM	OS	Tertile	All	1.000	0.881	.010	17	view →
CESC	OS	Quartile	All	0.770	0.485	.014	16	view →
KICH	OS	Quartile	All	0.611	1.000	.006	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ZSCAN16-AS1–SKCM (OS)

Open the SKCM breakdown →