ZSCAN12

Across TCGA pan-cancer cohorts, ZSCAN12 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZSCAN12 data layer compared with 27 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ZSCAN12 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZSCAN12 expression acts as an unfavorable survival marker, although some lineages such as CESC and UCEC show a favorable association.

CESC, UCEC, and LIHC are the cancer types where ZSCAN12 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	IV	1.000	0.170	.035	6	view →
UCEC	DFS	Median	III,IV	0.906	0.532	.041	6	view →
LIHC	OS	Median	All	0.105	0.774	.002	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZSCAN12–CESC (DFS)

Open the CESC breakdown →