ZSCAN12

Across TCGA patient cohorts, ZSCAN12 mutation is significantly associated with the RNA expression of many other genes, with 4,222 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN12-associated genes across cancer lineages are DEFB104A, OR10V1, and CXorf49. Each is linked with ZSCAN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN12-to-partner and partner-to-ZSCAN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB104A grouped by ZSCAN12-low versus ZSCAN12-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN12→partner) and Y-score (partner→ZSCAN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DEFB104A →	+0.059	+7.057	<.001	.009	3	2
SCLC	OR10V1 →	+0.130	+4.847	<.001	.009	3	1
SCLC	CXorf49 →	+0.043	+6.228	<.001	.001	3	1
BRCA	LIPC-AS1 →	+0.072	+3.817	.002	.009	3	1
BRCA	REXO1L8P →	+0.019	+5.365	<.001	.002	3	1
UCEC	COX5A →	+0.309	+2.702	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,222 associations by consensus.

DEFB104A by ZSCAN12 expression — BRCA

Explore this box plot interactively →