ZSCAN12

Across TCGA patient cohorts, ZSCAN12 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN12-associated genes across cancer lineages are Shc_pY317, 14-3-3_beta, and EGFR_pY1068. Each is linked with ZSCAN12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZSCAN12-to-partner and partner-to-ZSCAN12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by ZSCAN12-low versus ZSCAN12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN12→partner) and Y-score (partner→ZSCAN12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.193	-2.247	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.098	-3.673	.003	.001	3	1
UCEC	EGFR_pY1068 →	-0.282	-3.115	<.001	<.001	3	1
UCEC	EGFR →	-0.120	-2.584	.022	.010	3	1
UCEC	eIF4E →	+0.172	+3.335	.013	.005	3	1
UCEC	A-Raf_pS299 →	-0.123	-2.222	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Shc_pY317 by ZSCAN12 expression — UCEC

Explore this box plot interactively →