ZSCAN1

Across TCGA patient cohorts, ZSCAN1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZSCAN1-associated genes across cancer lineages are ERK2, Caspase-7-cleavedD198, and AR. Each is linked with ZSCAN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZSCAN1-to-partner and partner-to-ZSCAN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ZSCAN1-low versus ZSCAN1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZSCAN1→partner) and Y-score (partner→ZSCAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ERK2 →	+0.346	+3.012	.026	.018	3	3
COAD	Caspase-7-cleavedD198 →	+1.112	+3.178	.004	.010	3	3
LUAD	AR →	-0.159	-2.321	.027	.033	3	2
LUAD	TTF1 →	+1.022	+2.321	.021	.035	3	2
LUAD	Bap1-c-4 →	+0.253	+3.476	.005	.002	3	2
SKCM	p27_pT157 →	+0.152	+1.678	<.001	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ERK2 by ZSCAN1 expression — LUAD

Explore this box plot interactively →