ZRANB3

Across TCGA patient cohorts, ZRANB3 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZRANB3-associated genes across cancer lineages are ASNS, EGFR_pY1068, and p62 Lck ligand. Each is linked with ZRANB3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZRANB3-to-partner and partner-to-ZRANB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ZRANB3-low versus ZRANB3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZRANB3→partner) and Y-score (partner→ZRANB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.520	+1.700	<.001	.040	3	3
UCEC	EGFR_pY1068 →	-0.267	-3.087	.002	<.001	3	2
UCEC	p62 Lck ligand →	+0.467	+2.392	<.001	<.001	3	2
UCEC	PCNA →	+0.303	+2.392	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.668	+2.926	<.001	<.001	3	2
UCEC	ATM →	-0.429	-2.446	.007	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

ASNS by ZRANB3 expression — UCEC

Explore this box plot interactively →