ZRANB2

Across TCGA patient cohorts, ZRANB2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZRANB2-associated genes across cancer lineages are 14-3-3_beta, ERK2, and INPP4B. Each is linked with ZRANB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZRANB2-to-partner and partner-to-ZRANB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ZRANB2-low versus ZRANB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZRANB2→partner) and Y-score (partner→ZRANB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.084	-2.558	.018	.010	3	1
UCEC	ERK2 →	+0.180	+2.584	.008	.010	3	1
UCEC	INPP4B →	-0.248	-2.000	.029	.029	3	1
UCEC	JNK2 →	+0.237	+2.000	<.001	.003	3	1
UCEC	Ku80 →	+0.165	+1.375	.048	.024	3	1
UCEC	MEK1 →	+0.404	+2.584	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

14-3-3_beta by ZRANB2 expression — UCEC

Explore this box plot interactively →