ZRANB2

Across TCGA cell cohorts, ZRANB2 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZRANB2-associated genes across cancer lineages are PPDPFL, C10orf53, and ARGFX. Each is linked with ZRANB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZRANB2-to-partner and partner-to-ZRANB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPDPFL grouped by ZRANB2-low versus ZRANB2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZRANB2→partner) and Y-score (partner→ZRANB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPDPFL →	+0.040	+3.632	<.001	.003	3	1
LARGE_INTESTINE	C10orf53 →	+0.012	+3.632	<.001	.003	3	1
LARGE_INTESTINE	ARGFX →	+0.010	+4.022	<.001	.006	3	1
BLOOD_Lymphoma	PRAMEF1 →	+0.230	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	PRAMEF2 →	+0.140	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	ASB17 →	+0.022	+5.794	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PPDPFL by ZRANB2 expression — LARGE_INTESTINE

Explore this box plot interactively →