ZRANB2-AS2

Across TCGA pan-cancer cohorts, ZRANB2-AS2 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZRANB2-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZRANB2-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types ZRANB2-AS2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and LUSC are the cancer types where ZRANB2-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZRANB2-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−0.593	<.001	11	view →
KICH	Female	II,III,IV	−0.590	<.001	9	view →
LUSC	All	III,IV	−0.208	<.001	8	view →
KIRC	All	All	−0.121	<.001	7	view →
KIRP	Male	III,IV	−0.217	<.001	6	view →
UCEC	All	All	−0.135	.002	4	view →
COAD	Female	All	−0.053	.014	4	view →
LUAD	Female	II,III,IV	−0.135	.002	3	view →
READ	All	All	−0.182	.002	2	view →
CHOL	Male	All	+0.156	<.001	2	view →
ESCA	All	All	−0.142	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZRANB2-AS2–THCA

Open the THCA breakdown →