ZRANB1

Across TCGA pan-cancer cohorts, ZRANB1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ZRANB1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZRANB1 RNA is repressed in tumor relative to normal tissue. In most cancer types ZRANB1 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

THCA, BRCA, and KICH are the cancer types where ZRANB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZRANB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.844	<.001	9	view →
BRCA	All	III,IV	−0.446	<.001	6	view →
KICH	All	All	−0.693	<.001	5	view →
BLCA	All	All	−0.458	.020	5	view →
KIRP	Male	All	−0.636	<.001	4	view →
KIRC	Male	II,III,IV	−0.357	.012	4	view →
LUAD	Female	All	−0.353	.003	3	view →
UCEC	All	All	−0.901	<.001	2	view →
ESCA	All	II,III,IV	−0.375	.044	2	view →
ESCA	Female	All	+0.563	.002	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

ZRANB1–THCA

Open the THCA breakdown →