ZPR1

Across TCGA pan-cancer cohorts, ZPR1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ZPR1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ZPR1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZPR1 is over-expressed in tumor.

CCRCC, LSCC, and LUAD are the cancer types where ZPR1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZPR1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	+0.499	<.001	12	view →
LSCC	Male	All	+0.414	<.001	9	view →
LUAD	Female	II,III,IV	+0.306	<.001	9	view →
PDAC	Female	II,III,IV	+0.464	<.001	7	view →
HNSC	All	III,IV	+0.205	<.001	6	view →
COAD	Female	All	+0.197	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ZPR1–CCRCC

Open the CCRCC breakdown →