ZPR1

Across TCGA patient cohorts, ZPR1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZPR1-associated genes across cancer lineages are Caspase-7-cleavedD198, A-Raf_pS299, and FoxM1. Each is linked with ZPR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZPR1-to-partner and partner-to-ZPR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZPR1-low versus ZPR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZPR1→partner) and Y-score (partner→ZPR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.670	+2.604	.009	.005	3	3
UCEC	A-Raf_pS299 →	-0.160	-3.169	.002	.019	3	1
UCEC	FoxM1 →	+0.288	+2.115	.010	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.162	-2.459	.028	.019	3	1
UCEC	JNK2 →	+0.181	+2.115	.037	.019	3	1
UCEC	Notch1 →	+0.157	+2.335	.010	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Caspase-7-cleavedD198 by ZPR1 expression — UCEC

Explore this box plot interactively →