ZPLD2P

Across TCGA pan-cancer cohorts, ZPLD2P RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZPLD2P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ZPLD2P RNA is repressed in tumor relative to normal tissue. In most cancer types ZPLD2P is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

KIRP, THCA, and KIRC are the cancer types where ZPLD2P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZPLD2P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−1.900	<.001	11	view →
THCA	Male	III,IV	−1.755	<.001	11	view →
KIRC	Male	All	−1.647	<.001	11	view →
KICH	Male	All	−1.134	<.001	8	view →
HNSC	All	All	−0.186	<.001	7	view →
BRCA	Female	II,III,IV	−0.300	<.001	6	view →
COAD	All	All	+0.232	<.001	6	view →
CHOL	All	II,III,IV	−2.035	<.001	5	view →
LUSC	Male	II,III,IV	−0.262	<.001	5	view →
LUAD	All	II,III,IV	−0.212	.007	3	view →
PRAD	All	All	−0.481	<.001	2	view →
READ	All	All	+0.393	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZPLD2P–KIRP

Open the KIRP breakdown →