ZPLD1

Across TCGA patient cohorts, ZPLD1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZPLD1-associated genes across cancer lineages are ATM, Src_pY416, and EGFR_pY1068. Each is linked with ZPLD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZPLD1-to-partner and partner-to-ZPLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZPLD1-low versus ZPLD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZPLD1→partner) and Y-score (partner→ZPLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.491	-3.156	.008	.018	3	2
LUAD	Src_pY416 →	+0.387	+2.824	.039	.036	3	1
UCEC	EGFR_pY1068 →	-0.293	-2.321	.004	.006	3	1
UCEC	ERK2 →	+0.167	+1.807	.035	.027	3	1
UCEC	MEK1 →	+0.399	+2.584	.008	.010	3	1
UCEC	Rad50 →	-0.212	-1.807	.034	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by ZPLD1 expression — UCEC

Explore this box plot interactively →