ZPLD1

Across TCGA cell cohorts, ZPLD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 765 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZPLD1-associated GO terms across cancer lineages are Cell-substrate junction assembly, Regulation of protein modification by small protein conjugation or removal, and Positive regulation of protein ubiquitination. Each is linked with ZPLD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZPLD1-to-partner and partner-to-ZPLD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell-substrate junction assembly grouped by ZPLD1-low versus ZPLD1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZPLD1→partner) and Y-score (partner→ZPLD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cell-substrate junction assembly →	+0.153	+0.318	<.001	.001	3	5
LARGE_INTESTINE	Regulation of protein modification by small protein conjugation or removal →	+0.032	+0.073	.006	.004	2	5
LARGE_INTESTINE	Positive regulation of protein ubiquitination →	+0.027	+0.140	.007	<.001	3	4
LARGE_INTESTINE	Hemidesmosome assembly →	+0.155	+0.130	<.001	.002	3	4
LARGE_INTESTINE	Axoneme assembly →	-0.033	-0.154	.001	.006	3	4
LARGE_INTESTINE	Negative regulation of protein catabolic process →	+0.043	+0.122	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 765 associations by consensus.

Cell-substrate junction assembly by ZPLD1 expression — PANCREAS

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