ZP4

Across TCGA pan-cancer cohorts, ZP4 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated ZP4 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher ZP4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZP4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

THYM, LIHC, and PRAD are the cancer types where ZP4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
LIHC	DFS	Median	II,III,IV	0.040	0.427	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	All	0.956	0.612	.017	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
SKCM	OS	Median	II,III,IV	1.000	0.722	.011	6	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →
STAD	DFS	Median	III,IV	0.112	0.580	.005	3	view →
SCLC	DFS	Median	All	0.764	0.457	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

ZP4–THYM (OS)

Open the THYM breakdown →