ZNRF4

Across TCGA pan-cancer cohorts, ZNRF4 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ZNRF4 data layer compared with 17 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZNRF4 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZNRF4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC and LSCC are the cancer types where ZNRF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.927	0.500	.019	7	view →
LSCC	DFS	Median	All	1.000	0.865	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ZNRF4–CCRCC (OS)

Open the CCRCC breakdown →