Across TCGA patient cohorts, ZNRF3 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,190 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ZNRF3-associated proteins across cancer lineages are NCF4, STK10, and GPSM3. Each is linked with ZNRF3 in more than 7 cancer types. Because this analysis shows association rather than direction, both ZNRF3-to-partner and partner-to-ZNRF3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF3→partner) and Y-score (partner→ZNRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCF4 →	-0.635	-0.425	.002	.006	3	8
GBM	STK10 →	-0.457	-0.611	<.001	<.001	3	7
HNSC	GPSM3 →	-0.459	-0.739	<.001	.002	3	7
BRCA	MYEF2 →	+0.574	+0.597	<.001	<.001	3	7
GBM	DOK2 →	-0.589	-0.532	.003	.002	3	7
GBM	TNFAIP8 →	-0.621	-0.536	.004	<.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,190 associations by consensus.

Exploration

ZNRF3 survival (RNA) · tumor vs normal (RNA) · all ZNRF3 data types