Across TCGA patient cohorts, ZNRF3 mutation is significantly associated with the RNA expression of many other genes, with 2,188 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNRF3-associated genes across cancer lineages are LINC00351, AOC2, and TVP23B. Each is linked with ZNRF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNRF3-to-partner and partner-to-ZNRF3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF3→partner) and Y-score (partner→ZNRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC00351 →	+0.583	+3.450	<.001	.006	3	3
UCEC	AOC2 →	+0.788	+2.459	<.001	<.001	3	3
COAD	TVP23B →	+0.877	+3.183	<.001	.009	3	3
UCEC	TNFSF13B →	+0.551	+1.398	<.001	.004	3	3
UCEC	CMC2 →	+0.403	+1.842	<.001	.001	3	3
UCEC	PPP2CB →	+0.468	+1.805	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,188 associations by consensus.

Exploration

ZNRF3 survival (RNA) · tumor vs normal (RNA) · all ZNRF3 data types