Across TCGA patient cohorts, ZNRF3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNRF3-associated genes across cancer lineages are PCNA, ATM, and 4E-BP1. Each is linked with ZNRF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNRF3-to-partner and partner-to-ZNRF3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNRF3→partner) and Y-score (partner→ZNRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.198	+1.584	.003	.005	3	3
COAD	ATM →	-0.658	-3.161	<.001	.019	3	3
UCEC	4E-BP1 →	+0.206	+1.137	.015	.041	3	3
COAD	eIF4E →	+0.255	+2.820	.003	.035	3	2
UCEC	MEK1 →	+0.390	+2.392	<.001	<.001	3	2
UCEC	MSH2 →	-0.241	-1.973	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

ZNRF3 survival (RNA) · tumor vs normal (RNA) · all ZNRF3 data types