Across TCGA pan-cancer cohorts, ZNRF1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNRF1 data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZNRF1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNRF1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where ZNRF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.237	0.542	.011	12	view →
HNSC	DFS	Median	II,III,IV	0.984	0.870	.016	6	view →
LUAD	DFS	Median	III,IV	0.265	0.922	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ZNRF1 tumor-vs-normal RNA expression · all ZNRF1 data types